[Gatalis]

I know Shea keeps Black Lotus for tougher fights and for her highs (considering half the time she acts like she's on inderol anyways, she needs it lol), Milli keeps a dose of Kammarth for just those situations, generally. Since most items only provide up to 5/- DR or 10% immunity, a 10/- DR can make you pretty boss against most enemies (especially since as a heavy hitter Con or STR build, you probably won't have an AC that gets higher than 32 or so without major buffs, mounted combat, or excessive AC bonuses, and most enemies later on have ABs to match that of a max-STR fighter with twice the damage). The addiction risk is "high" but when you consider the fact that most fighters have a fort of 10+ by level 8 or 9, it's not too dangerous overall.

I'd assume Paladins would be straight edge unless they're like an Ilmatari one and took a plea of rest to go do evil shit (seriously, Plea of Rests are like... the best idea ever, thank you based Ilmater).